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| Rapid Determination of Polybrominated Diphenyl Ethers in Urine of Occupational Worker Using QuEChERS Coupled to Gas Chromatography-Mass Spectrometry |
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| DOI： |
| KeyWord:polybrominated diphenyl ethers(PBDEs) urine gas chromatography-mass spectrometry(GC-MS) occupational worker |
| Author | Institution |
| YU Dong，WANG De-jun，ZHU Wen-wen，CHEN Tian，SHI Zhi-xiong |
1.山东省职业卫生与职业病防治研究院检验科;2.山东省疾病预防控制中心;3.首都医科大学公共卫生学院 |
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| Abstract: |
| A method for the analysis of polybrominated diphenyl ethers(PBDEs) in urine of occupational worker was developed using QuEChERS(quick，easy，cheap，effective，rugged，safe) pretreatment coupled to gas chromatography-mass spectrometry(GC-MS).Urine sample was extracted with an acetone-hexane mixture by dehydration and salting-out using NaCl and anhydrous MgSO4.The purification was performed with C18 particlet,and GC-MS determination was perfomed under negative chemical ionization(NCI) mode.The calibration curves were linear in the ranges of 10-1 000 pg/μL for BDE-209，and 1-100 pg/μL for the rest of analytes，with correlation coefficients higher than 0.999 .The average recoveries were in the range of 91.7%-110.2% at three spiked levels，with relative standard deviations lower than 10%.The limits of detection(LOD) of PBDEs ranged from 0.3 pg/mL to 36 pg/mL.This method was validated to be simple，sensitive and selective，and was suitable for the exposure accessment of pollutant in occupational workers. |
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