Simultaneous Determination of 22 Toxic Volatile Organic Solvent Residues in Cosmetics by Static Headspace/Gas Chromatography-Mass Spectrometry
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KeyWord:static headspace  gas chromatography-mass spectrometry(GC-MS)  cosmetics  volatile organic compounds(VOCs)  determination
CHE Wen-jun,SHEN Jun,WANG Yan-qin,WANG Xiao-dan,PU Jie 1.苏州世谱检测技术有限公司;2.苏州卫生职业技术学院药学院;3.南京林业大学理学院
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      Based on the Safety and Technical Standards for Cosmetics(2015),a staticheadspace/gas chromatography-mass spectrometric(SHS/GC-MS) method was established to analyze 22 volatile organic compounds(VOCs) residues,including dichloromethane,cis-1,2-dichloroethene,trans-1,2-dichloroethylene,2-chloro-1,3-butadiene,trichloromethane,1,2-dichloroethane,benzene,carbon tetrachloride,trichloroethylene,methylbenzene,tetrachloroethylene,chlorobenzene,ethylbenzene,tribromomethane,m-xylene,p-xylene,phenylethylene,o-xylene,isopropylbenzene,1,4-dichlorobenzene,1,2-dichlorobenzene and hexachlorobutadiene in cosmetics.The experimental conditions for SHS/GC-MS,such as headspace conditions,analytical conditions of GC,quantitative ion’s selection and concentration of the samples were optimizedThe cosmetic samples were extracted and cleaned up by headspace at 80 ℃ for 30 min,determined and quantified by MS.22 kinds of VOCs had good linear relations in the range of 0.5-50 ng/mL with correlation coefficients higher than 0.99.The spiked recoveries ranged from 80.3% to 102.7%,with relative standard deviations(RSD) of 6.4%-9.9%.The limits of detection were in the range of 0.2-5.0 ng/g.This method had the advantages of simplicity,sensitivvity,accurancy, good reproducibility and stability,and was suitable for the screening and analysis of VOCs residues in cosmetics.