Preparation of Coated Cellulose Tri(4 methylbenzoate) Chiral Stationary Phases and Their Application in Enantioseparation
  
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KeyWord:coating  solvent  cellulose tri(4 methylbenzoate)  chiral stationary phases  enantiomers resolution
  
AuthorInstitution
WU Hai bo,XUE Xing ya,LI Kui yong,ZHOU Yong zheng 1.浙江华谱新创科技有限公司;2.中国科学院大连化学物理研究所分离分析化学重点实验室
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Abstract:
      Based on C8 modified macroporous silica,a coated cellulose tri(4 methylbenzoate)(CTMB) chiral stationary phases(CSPs) were prepared.Influences of coating solvent and additive on the enantioselectivity of CSP were investigated.Several CSPs were prepared by coating CTMB in chloroform and dichloromethane,with N,N’ dimethylformamide(DMF),phenol,nitrobenzene,methyl benzoate and acetophenone as additives,respectively.The enantioselectivities of CSPs were evaluated by using 7 structurally different enantiomers.It was found that column efficiency,retention ability and enantioselectivity of CSPs were affected by the type and amount of additive.The addition of the same amount of methyl benzoate with CTMB would provide the CSPs with better properties,which exhibit a good enantioseparation ability for racemic simendan intermediate and ketorolac,and possess an application potential in industrial preparation and separation.
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