Determination of 20 Aromatic Amines in Paper by Dispersive Solid Phase Extraction/Gas Chromatography-Triple Quadrupole Tandem Mass Spectrometry
  
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KeyWord:dispersed solid phase extraction(d-SPE)  gas chromatography-triple quadrupole tandem mass spectrometry(GC-MS/MS)  aromatic amines  paper
  
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周培琛,梁晖,邓其馨,张建平,黄延俊,黄华发,刘泽春,刘江生,许寒春,谢卫 福建中烟工业有限责任公司技术中心
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Abstract:
      A gas chromatography-triple quadrupole tandem mass spectrometry(GC-MS/MS) with dispersive solid phase extraction(d-SPE) was developed for the determination of azo colorants in paper.The azo colorants were reduced as aromatic amines after pretreatment.Sequentially,4 mL 10 mol/L sodium hydroxide solution,0.5 mL three internal standards(naphthalene-D8,2,4,5-trichloro-aniline and anthracene-D10)working solution,10 mL tert-butyl methyl ether and 15 g anhydrous sodium sulfate were added into the suspension to adjust the pH value from faintly acid to alkaline and absorb water.The aromatic amines were extracted with 10 mL tert-butyl methyl ether via 40 min thorough oscillation.The extract was further purified with d-SPE kits.After centrifugation,the supernatant was determined by GC-MS/MS in highly sensitive and selective multiple reaction monitoring mode(MRM),and quantified by internal standard method.There existed good linear relationships for the target compounds in respective concentration ranges,with their correlation coefficients(r2) larger than 0.99.The recoveries at three spiked levels of 10,20 and 50 ng/mL were between 80.7% and 128%,with the relative standard deviations(RSDs) of 0.79%-6.5%.The limits of detection(LODs) and limits of quantification(LOQs) were in the ranges of 0.05-2.1 ng/mL and 0.18-5.5 ng/mL,respectively.Results showed that the method was simple,rapid and sensitive,was applicable for the rapid detection of aromatic amines in paper.
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