Determination of 232 Pesticide Residues in Dairy Products by Gas Chromatography-Tandem Mass Spectrometry
  
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KeyWord:QuEChERS  GC-MS/MS  pesticide residues  dairy products
  
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WANG Jing, ZHANG Hai-chao, CHEN Min-na,AI Lian-feng,ZHANG Yi-qin Technology Center of Shijiazhuang Customs, Shijiazhuang , China
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Abstract:
      A gas chromatography-tandem spectrometric(GC-MS/MS)method was developed for the rapid determination of 232 pesticide residues in six kinds of dairy products. The samples were extracted with acetonitrile containing 1% acetic acid, then separated by liquid-liquid extraction with anhydrous sodium acetate and anhydrous magnesium sulfate, and followed by dispersive solid phase purification using anhydrous magnesium sulfate, C18 and PSA. The supernatant was concentrated under nitrogen, redissolved, then analyzed by GC-MS/MS under multiple reaction mode(T-MRM), and finally quantified by matrix matched internal standard method. Results showed that there existed good linear relationships for 232 pesticides with correlation coefficients more than 0.99. The limits of quantitation(LOQ)were in the range of 0.000 4-0.05 mg/kg. The spiked recoveries at three levels of 0.01, 0.02 and 0.10 mg/kg in milk were in the range of 65.2%-110%, with relative standard deviations(RSDs) of 3.6%-13%. This method is sensitive, reliable and accurate, and could be applied to the determination of 232 kinds of pesticide residues in dairy products, as well as the multi-pesticide residues in the routine analysis.
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