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| Construction of a Sol－Gel Molecularly Imprinted CsPbBr3 Quantum Dots Probe and Its Application in Fluorescence Detection of Cholesterol |
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| DOI： |
| KeyWord:sol－gel perovskite quantum dots cholesterol fluorescence sensor |
| Author | Institution |
| SONG Min-xia，GUAN Jie，CHEN Lu，SHU Yun，XU Qin，HU Xiao-ya |
School of Chemistry and Chemical Engineering， Yangzhou University， Yangzhou ， China |
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| Abstract: |
| In this work， CsPbBr3 quantum dots（QDs） were used as a new kind of fluorescence（FL）probe to detect cholesterol（CHO）. By using 3-aminopropyltrimethoxysilane（APTES） as the functional monomer and CHO as the template molecule， a CHO molecularly imprinted layer was formed on CsPbBr3 QDs via a simple silica sol－gel process. The formed silica layer not only improve the stability of CsPbBr3 QDs by protecting CsPbBr3 QDs from direct exposure to air and humidity， but also renders CsPbBr3 QDs good selectivity to CHO. During the detection process， CHO was captured into the specific cavity sites of CHO-imprinted SiO2 shell layers on CsPbBr3@SiO2 QDs to cause the decrease of the FL intensity of CsPbBr3 QDs. Under the optimal conditions， a good linear relationship was obtained between fluorescence quenching efficiency and the logarithm of CHO concentrations in the range of 1.00 × 10－11－5.00 × 10－8 mol·L－1， with a detection limit down to 2.48 × 10－12 mol·L－1. This sensor showed better sensitivity and selectivity to CHO than to other interferences. This work broadens the application horizon of CsPbBr3 QDs and provides a new strategy for CHO detection. |
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