水中全氟烷基醚类羧酸的超高效液相色谱－串联质谱检测方法研究

宋鑫; 王荣雨; 王晓; 纪文华

Analysis of Perfluoroalkyl Ether Carboxylic Acid in Water by Ultra- performance Liquid Chromatography－Tandem Mass Spectrometry

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KeyWord:perfluoroalkyl ether carboxylic acid（PFECA） ultra?performance liquid chromatography mass spectrometry in?source fragmentation neutral loss of molecule CO2

Author	Institution
SONG Xin,WANG Rong?yu,WANG Xiao,JI Wen?hua	1. Key Laboratory for Applied Technology of Sophisticated Analytical Instruments of Shandong Province，Shandong Analysis and Test Center，Qilu University of Technology（Shandong Academy of Sciences），Jinan ，China; 2. School of Pharmaceutical Sciences，Qilu University of Technology（Shandong Academy of Sciences）， Jinan ，China

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Abstract:

The abundance of excimer ion peaks could be decreased by the in?source fragmentation and neutral loss of molecule CO2 occurred within perfluoroalkyl ether carboxylic acids（PFECAs） under ESI source，which affects the detection sensitivity for PFECA. In this paper，［CF3（CF2）nO］ or ［M－H－CO2］ was selected as the parent ion，and fluorinated alkoxy and alkyl groups were selected as the daughter ions，which could increase the response of PFECAs by 4 orders of magnitude at most. Four PFECAs in water samples were detected by ultra?performance liquid chromatography－tandem mass spectrometry combined with liquid－liquid extraction. There were good linear relationships for the four analytes with their correlation coefficients（r2） larger than 0.99. The limits of detection and limits of quantitation were in the range of 0.001－0.005 ng/mL and 0.003－0.01 ng/mL，respectively. The spiked recoveries ranged from 90.2% to 108%，with relative standard deviations（RSD） not more than 7.9%. The method provides a platform for the accurate quantification and high sensitive detection of PFECAs.