Research Progress of Hemicyanine Dye for Molecular Imaging
  
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KeyWord:hemicyanine  ?molecular imaging  ?fluorescence imaging  ?multimodal imaging
  
AuthorInstitution
WU Fang-zheng,ZHANG Le-le,HAI Zi-juan Key Laboratory of Structure and Functional Regulation of Hybrid Materials,Ministry of Education,Institutes of Physical Science and Information Technology,Anhui University,Hefei ,China 2. School of Pharmacy,Guangdong Medical University,Dongguan ,China; 3. Guangdong Provincial Key Laboratory of Radionuclides Pollution Control and Resources,Guangzhou ,China
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Abstract:
      Molecular imaging has been widely applied to the research of fundamental biological processes,diagnosis,treatment design and therapeutic outcome assessment on many diseases.Hemicyanine(HCy) dye is a suitable bioimaging agent due to its good photophysical properties,biocompatibility and low toxicity to living systems.A huge amount of research work involving probes based on the HCy dye for molecular imaging has emerged in recent years.This review focuses on the development of probes based on HCy dye for fluorescence and multimodal imaging in a systematic manner.Design strategies of the activatable HCy probes and their successful applications as bioimaging agents are described in detail. In addition,the future development of HCy probes for molecular imaging is discussed.
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