Recent Progress in Nanoscale MOFs for Biological Imaging of Tumors and Tumor Markers
  
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KeyWord:nanoscale metal-organic frameworks(nMOFs)  ?biological imaging  ?tumor markers  ?biomedicine
  
AuthorInstitution
LIAO Xue-wei,LIU Yang,WANG Chen 1. Analytical & Testing Center,Nanjing Normal University,Nanjing ,China;2. School of Chemistry and Materials Science,Nanjing Normal University,Nanjing ,China;3. School of Environment,Nanjing Normal University,Nanjing ,China;4. State Key Laboratory of Analytical Chemistry for Life Science,Nanjing University,Nanjing ,China
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Abstract:
      Metal-organic frameworks(MOFs) have played important roles in a wide range of fields,such as gas storage and separation,fuel cells,energy conversion,and chemical/biological sensors.When one of the dimensions is scaled down to nanometer,MOFs can be named as nanoscale MOFs(nMOFs).Compared with the traditional MOFs,nMOFs retain the advantages of highly ordered porosity,structural tunability,more effective surface modification sites and improved biological distributions.nMOFs are biocompatible molecular nanomaterials with great potentials in various biomedical applications,especially for detection of tumors and tumor markers.In this review,recent progress in nMOFs for biological imaging of tumors and tumor markers is summarized.Different bioimaging techniques including fluorescence imaging,magnetic resonance imaging(MRI),photoacoustic imaging(PAI),computed tomography imaging(CTI),positron emission tomography imaging(PETI) are introduced.After that,multimodal imaging superimposed by two or more imaging modalities is highlighted. Finally,a brief conclusion about this special field is provided.Priorities of research in nMOF-mediated therapies and the prospects of clinical applications of nMOFs as delivery carriers and cancer therapeutics are also outlined.This review is expected to advance our understanding of this special field,and promote the applications of nMOFs in early diagnosis of disease and tumor therapy.
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