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| I-Motif-based Nanosystems for Biomedical Applications：pH Imaging，Drugs Controlled Release and Tumor Theranostics |
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| DOI： |
| KeyWord:i-motif ?pH imaging ?pH-controlled drugs release ?pH-responsive tumor theranostics |
| Author | Institution |
| MA Wen-jie，HUANG Jin，CHENG Hong，JIA Rui-chen，CHEN Biao，SUN Huan-huan，WU Yu-chen，HE Xiao-xiao，WANG Ke-min |
1. College of Biology，Hunan University，Changsha ，China;2. State Key Laboratory of Chemo/Biosensing and Chemometrics，College of Chemistry and Chemical Engineering，Hunan University，Key Laboratory for Bio-nanotechnology and Molecule Engineering of Hunan Province，Changsha ，China |
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| Abstract: |
| I-motif，as a novel pH-sensitive element，has attracted extensive attention and research upsurge in the field of biomedicine due to its ability of fast conformation alteration at different pH conditions，as well as the advantages of automatic synthesis，excellent biocompatibility and flexible functional integration．In this review，the basic performances of i-motif are firstly described．Then，the applications of i-motif-based nanosystems in biomedical field are reviewed from three aspects of cellular pH imaging，pH-controlled drugs release and pH-responsive tumor theranostics applications．Finally，some of the current challenges of the i-motif-based nanosystems for the biomedical applications are pointed out，and an insight into the future prospects of i-motif-based nanosystems for precision medicine is provided． |
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