Progress on Application of Endogenous Stimuli Responsive Strategies in Tumor Precision Theranostics
  
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KeyWord:endogenous  ?stimulus response  ?precision theranostics  ?tumor  ?research progress
  
AuthorInstitution
ZHAO Xu,WANG Meng-chao,ZHANG Kang-kang,YAN Xiu-ping 1. State Key Laboratory of Food Science and Technology,Jiangnan University,Wuxi ,China;2. International Joint Laboratory on Food Safety,Jiangnan University,Wuxi ,China;3. Institute of Analytical Food Safety,School of Food Science and Technology,Jiangnan University,Wuxi ,China
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Abstract:
      The microenvironment of tumor has a series of abnormal features,including low pH values,hypoxia,excess glutathione,increased oxidative stress and overexpressed enzymes.These endogenous factors play an important role in tumor proliferation,invasion,migration and neoangiogenesis,but they also provide opportunities for tumor precision diagnosis and treatment.The development of endogenous stimuli responsive platforms has become a research hotspot.Therefore,the design principles and the recent progress of various kinds of endogenous stimuli responsive diagnosis and treatment agents developed in recent years are summarized in this paper.The challenges and perspectives of the stimuli responsive platforms are discussed with a view to providing a theoretical basis for the construction of intelligent theranostics system.
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