Simple Synthesis of Ultra-small Size Focused Sulfur Quantum Dots for Fluorescence Sensing
  
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KeyWord:sulfur quantum dots  ?assembly-fission  ?dialysis post-treatment  ?ferric iron
  
AuthorInstitution
ZHENG Qiong-hua,SHENG Yi-lun,ZHANG Shan-biao,HUANG Zhong-nan,CHEN Wei,PENG Hua-ping Higher Educational Key Laboratory for Nano Biomedical Technology of Fujian Province,Department of Pharmaceutical Analysis,Fujian Medical University,Fuzhou ,China
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Abstract:
      A facile assembly-fission method combined with dialysis post-treatment strategy was adopted to prepare a kind of ultra-small size focused fluorescent sulfur quantum dots(SQDs).The as-prepared SQDs were characterized by transmission electron microscopy(TEM),energy-dispersive X-ray spectroscopy(EDX),UV-Vis absorption spectrometry(UV-Vis) and fluorescence spectrometry.The photoluminescence properties of the SQDs were investigated in detail,which indicated that the SQDs with the average diameter of 2.2 nm exhibited an excitation-independent emission and an optical stability in aqueous solution.Meanwhile,the fluorescence of the SQDs could be quenched by Fe3+ significantly,and the mechanism for the fluorescence quenching was via inner filter effect(IFE).Based on the fluorescence quenching effect of the Fe3+/SQDs system,a facile fluorescence sensing platform was successfully constructed for the highly selective and sensitive detection of Fe3+.The proposed SQD-based sensor showed a wide response to Fe3+ in the range of 5-600 μmol/L,with a detection limit(LOD) of 1.19 μmol/L.In addition,this method,with significant advantages of high sensitivity,high selectivity,simplicity and economy,was successfully applied to the detection of Fe3+ in human serum,avoiding the deficiencies of complex sample preparation and expensive detection conditions.Thus,this method has a potential application prospect in clinical diagnosis,and opens up a new way for the design of effective fluorescent probes for other biologically related targets.
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