Determination of 75 Pesticide Residues in Codonopsis Radix by Gas Chromatography-Tandem Mass Spectrometry with Dispersive Solid Phase Extraction Based on Hydroxylated Multi-walled Carbon Nanotubes
  
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KeyWord:hydroxylated multi-walled carbon nanotubes  dispersive solid phase extraction  gas chromatography-tandem mass spectrometry  pesticide residues  codonopsis radix
  
AuthorInstitution
YANG Zhi-min,CHANG Qiao-ying,LI Jian,XU Xiao-hui,XUE Hua-li,ZHU Ren-yuan 1. Key Laboratory of Pesticide and Veterinary Drug Monitoring for State Market Regulation,Lanzhou Institute for Food and Drug Control,Lanzhou ,China; 2. College of Food Science and Nutritional Engineering, China Agricultural University,Beijing ,China; 3. College of Science,Gansu Agricultural University,Lanzhou ,China; 4. State Key Laboratory of Food Nutrition and Safety, Tianjin University of Science & Technology,Tianjin ,China
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Abstract:
      A gas chromatography-tandem mass spectrometric(GC-MS/MS) method was developed for the rapid determination of 75 pesticide residues in codonopsis radix,based on modified dispersive solid phase extraction using hydroxylated multi-walled carbon nanotubes(MWCNTs-OH) as sorbent.The samples were extracted with ethyl acetate,then salted out and cleaned up with anhydrous magnesium sulfate,sodium acetate,N-primary secondary amine(PSA) and MWCNTs-OH,finally analyzed by gas chromatography-tandem mass spectrometry in the dynamic multiple reaction monitoring(dMRM) mode and quantified by the matrix-matched external standard method.There were good linear relationships for 75 pesticides in the range of 5-300 μg/L,with correlation coefficients(r2) no less than 0.996 1.The limits of detection(LODs) and the limits of quantitation(LOQs)were 0.001-0.054 mg/kg and 0.002-0.178 mg/kg,respectively.The average recoveries at four spiked levels of 0.025,0.05,0.20 and 0.50 mg/kg ranged from 69.7% to 113%,with relative standard deviations(RSDs,n = 4) of 0.64%-6.7%.This method is simple,rapid and accurate,and it is suitable for high-throughput detection of pesticide residues in codonopsis radix.
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