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| Determination of Migration Amounts of 5 Compounds in Food Contact Rubber Liners by High Performance Liquid Chromatography－Tandem Mass Spectrometry |
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| DOI： |
| KeyWord:food contact rubber liners high performance liquid chromatography－tandem mass spectrometry（HPLC－MS/MS） food simulants migration |
| Author | Institution |
| CHEN Yin-qing，LI Zi-cheng，TONG Xing，CHEN Jie，GE Dan-yang，PENG Qi-shan，LI Dan，HU Chang-ying |
1. Department of Food Science and Engineering，Jinan University，Guangzhou ，China; 2. National Reference Laboratory of Food Contact Material（Guangdong），Guangzhou Customs Technology Center，Guangzhou ，China; 3. Key Laboratory of Product Packaging and Logistics of Guangdong Higher Education Institutes，College of Packaging Engineering，Jinan University，Zhuhai ，China |
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| Abstract: |
| A method was developed for the determination of the migration amounts of 5 compounds，i.e.aniline，N-methylaniline，1，3-diphenylguanidine，2-mercaptobenzothiazole and benzothiazole in food contact rubber liners by high performance liquid chromatography－tandem mass spectrometry（HPLC－MS/MS）．The separation of target compounds was performed with an Agilent Poroshell 120EC－C18 column（3 mm × 50 mm，2.7 μm），using 0.1%（volume fraction） formic acid and acetonitrile solution as mobile phases by gradient elution．The detection on the analytes was performed with positive electrospray ionization source under multiple reaction monitoring（MRM） mode，and the quantitation was carried out by the external standard method．Under the optimized conditions，the calibration curves were linear in the respective mass concentration ranges，with correlation coefficients（r2） not less than 0.996 6．The limits of detection（LODs，S/N = 3） and quantitation（LOQs，S/N = 10） were in the ranges of 0.8－20 μg/L and 3－50 μg/L，respectively．The average recoveries for 5 compounds at the spiked levels of 3－500 μg/L were in the range of 93.4%－112%，with relative standard deviations（RSDs） of 0.70%－4.3%．This method was used to detect the migration amounts of 5 compounds in 10 kinds of food contact rubber liners under the three conditions（40 ℃ for 10 min，40 ℃ for 30 min and 40 ℃ for 120 min）．According to the migration results，5 compounds in all liners were detected，and the migration amounts of 1，3-diphenylguanidine and 2-mercaptobenzothiazole were within the limit range．The detection of benzothiazole needs attention．The migration amounts of aniline and N-methylaniline were higher than its migration limit（0.01 mg/kg），and the generation of aniline and N-methylaniline must be controlled by improving the formulation or the process．This method has the advantages of simple operation and high sensitivity，and it is suitable for the determination of 5 compounds in food contact rubber liners． |
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