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| Determination of Migration of 50 Additives in Food Contact Plastics by Ultra-performance Liquid Chromatography－Quadrupole Time-of-flight Mass Spectrometry |
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| DOI： |
| KeyWord:plastic additives migration food contact materials ultra-performance liquid chromatography－quadrupole time-of-flight mass spectrometry |
| Author | Institution |
| LI Zi-cheng，WU Xue-feng，DONG Ben，LI Dan，ZHONG Huai-ning，CHEN Yan-fen，ZHENG Jian-guo |
National Reference Laboratory for Food Contact Material（Guangdong），Guangzhou Customs District Technology Center，Guangzhou ，China |
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| Abstract: |
| In order to assess the risks from the migration of additives in food contact plastics，a method for simultaneous determination of the migration of 50 additives in food contact plastics was established by ultra-performance liquid chromatography－quadrupole time-of-flight mass spectrometry（UPLC－QTOF MS）．Methanol and the aqueous mixture of formic acid（0.01%，volume fraction） and 5 mmol/L ammonium acetate were adopted as the mobile phases for elution．The primary and secondary ions of the target were monitored in target ion acquisition（Target MS/MS） mode．The results of each substance showed good linear relationships in the mass concentration range of 0.02－5 mg/L．The detection limits of the method were between 0.01 mg/kg and 0.1 mg/kg，and the spiked recoveries ranged from 92.6% to 104%，with the relative standard deviations（RSDs） of 0.60%－8.4%．A total of 12 plastic samples were detected in 20 actual samples，of which nonylphenol was detected in 2 samples，and the migration amounts were 0.033－0.071 mg/kg．Meanwhile，antioxidant 1076 and antioxidant 168 were found in 6 samples，and the migration amounts ranged between 0.12 mg/kg and 3.3 mg/kg，while photoinitiator 369，photoinitiator ITX and photoinitiator TPO were detected in 4 samples，and the migration amounts were between 0.054 mg/kg and 4.0 mg/kg. The method is sensitive，accurate and simple，and it is suitable for the detection of migration of 50 additives in plastics for food contact materials. |
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