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| Determination of 10 N-Nitrosamines in Cosmetics by QuEChERS/Gas Chromatography－Tandem Mass Spectrometry |
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| DOI： |
| KeyWord:gas chromatography－tandem mass spectrometry QuEChERS cosmetics N-nitrosamines |
| Author | Institution |
| ZHANG Jing，ZENG Min-shan，LAI Jun-min，LI Si-yuan，YAN Xiao-hong，DING Yi |
Guangzhou Institute for Drug Control，Guangzhou ，China |
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| Abstract: |
| A gas chromatography－tandem mass spectrometric（GC－MS/MS） method was established for the simultaneous detection of 10 N-nitrosamines including N-nitrosodimethylamine in cosmetics. After pretreated by QuEChERS method，the samples were extracted with acetonitrile，then purified by enhanced lipid removal products（EMR－Lipid dSPE）. The analytes were separated on a polyethylene glycol quartz column HP－INNOWAX（30 m × 0.25 mm × 0.25 μm），then analyzed in multiple reaction monitoring（MRM） mode，and finally quantified by the external standard method. There were good linear relationships for the 10 N-nitrosamines in the range of 0.5－50 ng/mL，with their correlation coefficients（r） larger than 0.999. The limits of detection and limits of quantitation were 1 μg/kg and 3 μg/kg，respectively. The average recoveries for 10 N-nitrosamines at the spiked levels of 5， 50，200 μg/kg ranged from 80.5% to 143%，with the relative standard deviations（RSDs） less than 11%（n = 6）. The developed method was simple，rapid，exclusive，sensitive，accurate and precise，and it could be applied in the rapid determination of 10 N-nitrosamines in cosmetics. |
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