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| Research Progress on Application of High-resolution Mass Spectrometry in Analysis of PFAS |
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| DOI： |
| KeyWord:perfluoroalkyl and polyfluoroalkyl substances（PFAS） high-resolution mass spectrometry review |
| Author | Institution |
| WANG Zhen-ju，LUO Xin，LIANG Sheng-kang，TANG Zhi-xu，YE Xi-wen，MA Qiang，NIU Zeng-yuan |
1. College of Chemistry and Chemical Engineering，Ocean University of China，Qingdao ，China; 2. Technology Center of Qingdao Customs District，Qingdao ，China; 3. Chinese Academy of Inspection and Quarantine，Beijing ，China |
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| Abstract: |
| Perfluoroalkyl and polyfluoroalkyl substances（PFAS） are widely used in industrial production and daily life．PFAS have been widely studied and consequently been detected in various environmental and biological matrices around the world due to their potential threats to humans and the environment．The development trend of relevant regulations is to manage PFAS as a chemical class. To date，mass spectrometry（MS） has been a traditional technique for PFAS analysis，among which the low-resolution MS is only limited for target analysis，while high-resolution MS with advantages of high resolution and high mass accuracy，could realize the high throughput analysis for both targets and non-targets at the same time，so as to meet and respond to the requirements for continuous updating and stricter of regulations．The research progress on high-resolution MS in PFAS analysis，including related pretreatment methods are reviewed in this paper．Furthermore，the applications of high-resolution MS in environmental samples，food，consumer goods，human samples and other matrix are also introduced，and the process of non-targeted analysis is described．Finally，knowledge gaps and future perspectives are identified． |
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