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| Progress on Mass Spectrometry Imaging Technology and Its Application |
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| DOI： |
| KeyWord:mass spectrometry imaging secondary ion mass spectrometry matrix-assisted laser desorption ionization mass spectrometry ambient ionization mass spectrometry spatially resolved metabolomics |
| Author | Institution |
| ABLIZ Zeper |
1. Key Laboratory of Mass Spectrometry Imaging and Metabolomics，State Ethnic Affairs Commission，Minzu University of China，Beijing ，China; 2. State Key Laboratory of Bioactive Substance and Function of Natural Medicines，Institute of Materia Medica，Chinese Academy of Medical Sciences and Peking Union Medical College，Beijing ，China |
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| Abstract: |
| In this paper，the progresses of mass spectrometry imaging（MSI） techniques，including secondary ion mass spectrometry（SIMS），matrix-assisted laser desorption ionization mass spectrometry（MALDI－MSI） and ambient ionization mass spectrometry（Ambient MSI），as well as their applications have been summarized．MSI could be applied in the analysis of biological tissues or cells for not only some specific molecules but also known and unknown molecules simultaneously since it is a visual analytical method of label-free，high coverage and high sensitivity．The spatial distributions，relative contents，and structures of different molecules could thus be obtained simultaneously，to realize their qualitative and quantitative analysis，and position as well. Moreover，it can also provide the dynamic spatial and temporal changes of functional molecules in different physiological and pathological processes．Therefore，MSI has become one of the research frontiers and hot directions in the field of mass spectrometry and analytical chemistry and shows great application prospects in the fields of chemistry，medicine，life science，pharmacy，and environmental science．In addition，MSI is a powerful tool for single-cell visual analysis and spatially resolved metabolomics．It can help to obtain the spatio-temporal molecular dynamic profiling of things in different spatial scales，such as cells，organs，and even whole body． |
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