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| Research Progress on Application of High-resolution Mass Spectrometry in Analysis of Traditional Chinese Medicines |
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| DOI： |
| KeyWord:high resolution mass spectrometry traditional Chinese medicine material basis metabolism plant metabolomics harmful chemical components |
| Author | Institution |
| ZHOU Xi，LUO Hui-tai，LAI Xiao-na，HUANG Fang，WU Hui-qin |
Guangdong Provincial Engineering Research Center for Quality and Safety of Traditional Chinese Medicine，Guangdong Provincial Key Laboratory of Chemical Measurement and Emergency Test Technology，Institute of Analysis，Guangdong Academy of Sciences（China National Analytical Center），Guangzhou ，China |
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| Abstract: |
| The analysis of traditional Chinese medicine（TCM） involves many fields such as material basis research，drug metabolism and quality control，which is the basis for the modernization of TCM. With the development of modern analytical technology，great progress has been made in the study of TCM. In view of the difficulties of complex components，diverse metabolic processes and low concentration of analytes，the advantages of high-resolution mass spectrometry technology such as accurate mass number，high resolution and high sensitivity have obvious predominance in TCM analysis. This review summarizes the progress on mass spectrometry，including quadrupole time of flight mass spectrometry，orbitrap mass spectrometry，Fourier transform ion cyclotron resonance mass spectrometry and ion mobility spectrometry，as well as the application of high resolution mass spectrometry in the analysis of TCM，including chemical components identification，compound metabolism，plant metabolomics of TCM and harmful chemical components analyzing. Meanwhile，the application prospect of high resolution mass spectrometry is also discussed. It is hopeful to promote the modernization of traditional Chinese medicine. |
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