Determination of 82 Risk Chemicals in Plant Mosquito Repellent Products by Gas Chromatography-Tandem Mass Spectrometry
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KeyWord:gas chromatography-tandem mass spectrometry(GC-MS/MS)  mosquito repellent product  allergenic aromatics  pesticide
LI Hong-yan,LIU Ying,LI Chang-yu,WANG Jin 1. Zhejiang Institute of Product Quality and Safety Science,Hangzhou ,China; 2. Ecology and Health Institute,Hangzhou Vocational & Technical College,Hangzhou ,China; 3. Zhejiang Fangyuan Testing Group Co. Ltd.,Hangzhou ,China
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      A solvent extraction/gas chromatography-tandem mass spectrometry(GC-MS/MS) was established for the simultaneous detection of 78 allergenic aromatics and 4 pesticide compounds in plant mosquito repellent products.The polar chromatographic column Agilent VF-WAXms was used for chromatographic separation,and some of the co-efflux compounds were analyzed qualitatively and quantitatively by different characteristic ion pairs.The extraction conditions of samples were optimized by using positive samples as the research object.The contents of multiple target substances in the samples were compared under different extraction solvents and different extraction time conditions.The optimal extraction conditions were determined by using dichloromethane as the extraction solvent and ultrasonic extraction at 30 ℃ for 30 min.The results showed that there were good linear relationships for 82 target compounds in the respective concentration ranges,with their correlation coefficients(r) larger than 0.992 0.The limits of quantitation were in the range of 0.02-5.0 mg/kg.The recoveries ranged from 60.0% to 120%,with relative standard deviations(RSDs) not more than 9.5%.The method was used to screen 29 samples including mosquito repellent stickers,mosquito repellent buttons,mosquito repellent liquids and mosquito repellent gels.A total of 33 allergenic aromatics and 1 pesticide(ethyl butylacetylaminopropionate) were detected.11 allergenic aromatics including α-pinene,β-pinene and D-limonene were found in more than 80% of the samples,with a maximum content range of 116-21 140 mg/kg.Meanwhile,ethyl butylacetylaminopropionate was detected in 3 mosquito repellent liquids,with a content range of 10 200-21 350 mg/kg.This method is simple,accurate and reliable,and it could be used for the simultaneous targeted screening and determination on allergenic aromatics and pesticides in mosquito repellent products.