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| Design， Preparation of Monolithic Column and Its Recent Progress in Application of Sample Pretreatment |
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| DOI： |
| KeyWord:monolithic column（MC） sample pretreatment solid phase microextraction（SPME） preparation application |
| Author | Institution |
| WANG Xue-mei，YUAN Na，HUANG Li-xia，HUANG Peng-fei，DU Xin-zhen，LU Xiao-quan |
Key Laboratory of Bioelectrochemistry and Environmental Analysis of Gansu Province，Key Lab of Eco－Environments Related Polymer Materials of MOE，College of Chemistry and Chemical Engineering， Northwest Normal University，Lanzhou ，China |
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| Abstract: |
| Monolithic column（MC） is a uniform and stable rod-shaped entity formed by in-situ polymerization of reaction monomer，crosslinking agent and pore-forming agent in tubular materials such as capillary or chromatographic column under certain conditions，so it is also called rod-shaped column，continuous bed，etc．MC could be divided into three types according to the types of material used，i.e．organic monolithic columns，inorganic monolithic columns and organic-inorganic hybrid monolithic columns．Capillary monolithic column has all the advantages of solid-phase microextraction（SPME） as it belongs to in-tube solid-phase microextraction（In-tube SPME），integrating sampling，extraction，concentration，injection and other steps．Compared with coating fiber and open tubular capillary，MC possesses more extraction sorbent and exhibits higher extraction capacity．In comparison to the particle-filled column，the preparation procedure of MC does not need to be packed．In addition，the monolithic porous structure facilitates convective mass transfer procedure preferable in extraction process，which helps to complete the extraction procedure within a shorter time．With the advantages of simple operation，rapidness，high efficiency，low consumption and high sensitivity，MC is suitable for the analysis of constant，trace and even ultra-trace samples，which is on-line with the trend of environment-friendly，miniaturized and automated sample pretreatment technology，and is of great significance in the field of sample pretreatment．In this review，the design，preparation and application progress of MC in the field of sample pretreatment in recent years are summarized，and its future development trend is prospected，which provides a reference for the design and preparation of MC in this field. |
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