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| Separation of Polymer Impurities in Cefuroxime Sodium by Polystyrene based Gel Filtration Chromatography |
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| DOI：10.3969/j.issn.1004-4957.年份.月份 |
| KeyWord:polystyrene gel MKF GPC 100 cefuroxime sodium condensation impurity |
| Author | Institution |
| NI Jingwen1，WEI Rongqing1，LIU Xiaoning1，FANG Shuo1，YUAN Yaozuo2，ZHANG Mei2 |
1.南京工业大学生物与制药工程学院色谱中心;2.江苏省药品检验所 |
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| Abstract: |
| A polystyrene based gel filtration chromatographic method was established for the isolation and examination of condensation impurity in cefuroxime sodium.The sample was separated with MKF GPC 100（100 mm×78 mm,5 μm） column uisng 001 mol/L phosphate buffer（pH 70）-acetonitrile（70∶30,by volume） as mobile phase.The flow rate was set at 10 mL/min and the detecting wavelength was set at 254 nm.The result indicated that the cefuroxime sodium was successfully separated from condensation impurity in 10 min.The method showed the advantages of simplicity and rapidness. |
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