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| Absorption Spectra and Resonance Rayleigh Scattering Spectra of Cu（Ⅱ)-Fluoroquinolone Chelates with Tetrachlorotetraiodo-fluoresceindisodium Salt System and Their Analytical Applications |
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| DOI：10.3969/j.issn.1004-4957.年份.月份 |
| KeyWord:moxifloxacin gatifloxacin tetrachlorotetraiodo-fluoresceindisodium salt Cu（Ⅱ) resonance rayleigh scattering |
| Author | Institution |
| 刘弘，李勤，杨季冬 |
1.西南大学化学化工学院;2.重庆三峡学院化学与环境学院;3.重庆三峡职业学院农业工程系 |
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| Abstract: |
| In pH 4.2-4.8 Britton-Robinson（B-R) buffer solution，moxifloxacin（MXFX) and gatifloxacin（GTF) of fluoroquinolone antibiotics（FLQs) could react with Cu（Ⅱ) to form chelate cations，which further bind with tetrachlorotetraiodo-fluoresceindisodium salt（Tf ) to form FLQs∶Cu（Ⅱ)∶Tf （ 1∶1∶1) ion association complexes.The system reactions resulted in the great enhancement of resonance Rayleigh scattering（RRS) and new RRS spectra appeared.The reaction systems of two drugs had similar spectral characteristics，the maximum RRS wavelength situated at 373 nm，and one small scattering peak situated at 590 nm.The intensities of RRS at 373 nm are proportional to the concentrations of antibiotics drugs in the ranges of 0.031-7.8 mg/L for MXFX and 0.029-9.0 mg/L for GTF.Based on this，a new method was developed for the determination of FLQs in capsule and human urine samples.The reaction mechanism and the reasons for RRS enhancement of the system were also investigated. |
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