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| Electrochemical Behavior and Determination of Paracetamol at Molecular Imprinted Film Modified Glassy Carbon Electrode |
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| DOI：10.3969/j.issn.1004-4957.年份.月份 |
| KeyWord:paracetamol molecular imprinted film glassy carbon electrode electrochemistry in-situ polymerization UV irradiation |
| Author | Institution |
| 周清，刘岚， 翟海云，朱明芳，张珍英 |
1.广东药学院药科学院; 2.中山大学化学与化学工程学院 |
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| Abstract: |
| Using paracetamol（PCT） as template and methylacrylic acid as functional monomer, a molecular imprinted polymer film was synthesized on the surface of glassy carbon electrode（GCE） through in-situ polymerization by UV irradiation.After the template was removed with methanol and formic acid mixture solution, a paracetamol imprinted polymer film modified glassy carbon electrode（MIP-GCE） was prepared, and a method for the determination of PCT was developed with MIP-GCE.The sensor exhibited a good selectivity and sensitivity.The calibration curve was linear in the range of 5.0×10-5-1.0×10-3 mol?L-1 with a detection limit of 1.4×10-6 mol?L-1.The method was applied in the determination of PCT in drugs, with recoveries of 96%-105%. |
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