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| Advances of Chromatography Technology in Study of Propranolol Enantiomers Pharmacokinetics |
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| DOI：10.3969/j.issn.1004-4957.年份.月份 |
| KeyWord:chromatography propranolol enantiomer chiral separation pharmacokinetics application |
| Author | Institution |
| 张娟红，王荣，谢华，孟宪栋，贾正平，武晓玉，李文斌，谢希晖 |
1.兰州军区兰州总医院全军高原损伤防治重点实验室;2.兰州大学药学院 |
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| Abstract: |
| Propranolol(PPL) is a nonselective blocking agent of β-adrenoceptor and it has many pharmacology effects.Propranolol is used clinically as racemics with partes aequales of S- and R-propranolol,but the β-adrenoceptor blocking effects of S is 100 times more than that of R-propranolol，and the R form is known to have antioxidant activities.It is important in chiral separation for propranolol enantiomers pharmacokinetics.In this paper,the applications of chromatographic method in resolution of propranolol enantiomers and their pharmacokinetics were reviewed by consulting and summarizing references in order to supply a reference for their further exploitation. |
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