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| Determination of Migration Levels of N-nitrosamines and N-nitrosatable Substances in Balloons and Carcinogenic Risk Exposure Level of NDMA in Balloon to Children |
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| DOI：10.3969/j.issn.1004-4957.年份.月份 |
| KeyWord:balloon N-nitrosamine N-nitrosatable substances gas chromatography-tandem mass spectrometry carcinogenic risk exposure |
| Author | Institution |
| 幸苑娜，王欣，陈泽勇,林浩学 |
深圳市计量质量检测研究院绿色技术研发中心 |
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| Abstract: |
| A method for the determination of migration levels of 7 N-nitrosamines and N-nitrosatable substances was developed using Sep-Pak AC2 connected to Dry cartridges and gas chromatography-tandem mass spectrometry.Its analytical tolerances for N-nitrosamines and N-nitrosatable substances in balloon were 1.25 μg/kg and 5.00 μg/kg,respectively.The average recoveries of 7 N-nitrosamines at a spiked concentration of 2.5 μg/kg ranged from 85% to 103% with RSDs（n=3） not more than 4.6%.N-nitrosodimethylamine（NDMA） and N-nitrosodiethylamine（NDEA） and their precursors were the most frequently nitrosamines and nitrosatable substances found in balloon samples,while N-nitrosomorpholine（NMOR）,N-nitrosopiperidine（NPIP） and N-nitrosodipropylamine（NDPA） and their precursors were not found in all balloon samples.The total migration values for 7 N-nitrosamines and N-nitrosatable substances in balloon samples were in the range of 0.036-0.964 mg/kg and 0.259-8.436 mg/kg,respectively.The risk exposure level of NDMA via oral intake from each balloon to children aged from 6 months to 4 years was grouped in the class of 0.010 mg/kg to 0.030 mg/kg body weight,which would bring high carcinogenic risk to children potentially. |
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