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| Determination of Paracetamol in Pharmaceuticals by Fe3+-H2O2-Dichlorofluorescein Chemiluminescence System |
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| DOI：10.3969/j.issn.1004-4957.年份.月份 |
| KeyWord:Flow-injection chemiluminescence dichlorofluorescein paracetamol |
| Author | Institution |
| 樊雪梅，王书民，尹治民，苏智魁，陈凤英，王宪生，崔凤灵 |
1.商洛学院化学与化学工程系;2.富平县食品药品监督管理局淡村所;3.河南师范大学化学与环境科学学院 |
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| Abstract: |
| A novel flow-injection chemiluminescence method was developed for the determination of paracetamol,which was based on the chemiluminescence reaction between paracetamol and hydroxy free radical produced by Fe3+ and H2O2 solution in the presence of dichlorofluorescein as energy transfer in the chemiluminescence system．Various factors influencing the chemiluminescence system were investigated and the possible mechanism was also discussed.Under the optimum conditions,the linear range for the determination of paracetamol was 8.0×10-8-5.0×10-5 mol/L with a detection limit（S/N=3） of 5.0×10-9 mol/L,the relative standard deviation（RSD,n=9） was 2.2% for 3.5×10-6 mol/L paracetamol solution.The method was successfully applied in the determination of paracetamol in pharmaceutical sample. |
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