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| Simultaneous Determination of Organophosphorous Flame Retardants in Children’s Toys by High Performance Liquid Chromatography-Mass Spectrometry |
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| DOI：10.3969/j.issn.1004-4957.年份.月份 |
| KeyWord:ultrasonic-assisted extraction high performance liquid chromatography- mass spectrometry toy organophosphorous flame retardants |
| Author | Institution |
| 高欣，郑如兰,戴传云,苏小东,雷绍荣 |
1.北京出入境检验检疫局;2.重庆科技学院化学化工学院; 3.四川省农科院分析测试中心 |
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| Abstract: |
| An effective method was established for the simultaneous determination of three kinds of organophosphorous flame retardants including tris-(2-chloroethyl)-phosphate(TCEP),tris-(1,3-dichlorepropyl)-phosphate(TDCP) and tris(chloro-2-propyl) phosphate(TCPP) in children’s toys,based on ultrasonic assisted extraction coupled with high performance liquid chromatography-mass spectrometry．Effects of extraction solvent type,extraction time and mobile phase on extraction efficiencies were investigated.The optimal conditions were as follows:extraction solvent:acetone,extraction time:25 min,mobile phase:water containing 0.05% formic acid-acetonitrile.Under the optimal conditions,the calibration curves were linear in the ranges of 1.0-500 μg/L for TCEP,10-500 μg/L for TCPP and 10-500 μg/L for TDCP,respectively,with correlation coefficients more than 0.997,The quantitation limits for TCEP,TCPP and TDCP were 0.5,8.0,6.0 μg/kg,respectively.The spiked recoveries varied from 83.4% to 98.9% with relative standard deviations of 4.0%-7.7%．The proposed method was successfully applied in the determination of organophosphorous flame retardants in commercially available toys including plastic children’s toys and stuffed children’s toy．The method developed is simple,rapid,sensitive and accurate,and could satisfy the demand for analysis of banned organpphosphorous flame retardants in children’s toys. |
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