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| Determination of 15 Fragrance Allergens in Toys by Supercritical Carbon Dioxide Fluid Extraction |
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| DOI：10.3969/j.issn.1004-4957.年份.月份 |
| KeyWord:supercritical carbon dioxide fluid extraction gas chromatography-mass spectrometry fragrance allergen toy |
| Author | Institution |
| 郑琳，林力,曹国洲,王谦,金献忠,卫碧文,曹良惠 |
1.宁波出入境检验检疫局;2.上海出入境检验检疫局 |
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| Abstract: |
| A method of supercritical CO2 fluid extraction gas chromatography-mass spectrometry (GC-MS) was developed for the determination of fragrance allergens in toy material.The optimal conditions were as follows:extraction temperature:50 ℃,pressure:300 bar;carbon dioxide flow rate:30 g/min; content of methanol entrainer:3%,dynamic extraction:30 min;static extraction time:30 min.Under the optimal conditions,the extracts were separated on a DB-17MS column,then determined by GC-MS and quantified by the internal standard method.The calibration curves were linear in the range of 0.02-60 μg/mL with correlation coefficients of 0.993 2-0.999 9 and detection limits(S/N=10) of 0.02-0.09 μg/mL.The average recoveries of the target compounds in polypropylene(PP),polyethylene(PE),alkyl benzo sulfonate(ABS) plastic samples were in the ranges of 79.6%-114.5%,75.0%-118.9% and 72.7%-114.9%，respectively.The relative standard deviations were in the ranges of 3.2%-11.0%,0.6%-11.6%,3.5%-11.0%.The results showed that this method was sensitive,reliable and environmental for the qualitative and quantitative determinations of fragrance allergens in toy product. |
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