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| Electrochemistry Study of Tetrandrine on Glass Carbon Electrode and Its Interaction with DNA |
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| DOI：10.3969/j.issn.1004-4957.年份.月份 |
| KeyWord:tetrandrine DNA electrochemistry interaction |
| Author | Institution |
| 王融融,程旺兴,黄美玲,单楚 |
安徽中医药大学药学院 |
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| Abstract: |
| The electrochemical behaviors of tetrandrine at glassy carbon electrode as well as its interaction with DNA were studied using cyclic voltammetry,differential pulse voltammetry,controlled potential electrolysis and ultraviolet-visible spectroscopy.The results indicated that the electrochemical oxidation of tetrandrine was an irreversible process and the electrode process was controlled by the diffusion step,and the parameters of electrochemical kinetics were investigated.The results showed that the electrode process of tetrandrine on glassy carbon electrode was two electrons and two hydrions transfered,and the electron transfer coefficient was 0.62.In the presence of DNA,the oxidation current of tetrandrine was decreased considerably,and the peak potential was shifted to the positive direction,which suggested that the binding of tetrandrine to DNA was via intercalation.The association constant（β） and stoichiometric coefficient（m） were calculated to be 4.27×103 and 1,respectively. |
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