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| Quality Evaluation of Nongsuo Danggui Wan and Danggui Pian Based on HPLC Fingerprints Combined with Chemometric Methods |
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| DOI：10.3969/j.issn.1004-4957.年份.月份 |
| KeyWord:HPLC fingerprints Nongsuo Danggui Wan Danggui Pian similarity evaluation chemometric methods |
| Author | Institution |
| WANG Zhen-zhong,SHAO Shi-jun |
1.中国科学院兰州化学物理研究所,中国科学院西北植物资源化学重点实验室/甘肃省天然
药物重点实验室;2.中国科学院大学 |
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| Abstract: |
| The chromatographic fingerprints combined with chemometric methods including principal component analysis（PCA） and hierarchical clustering analysis（HCA） have been applied to evaluate the quality consistency and stability of Nongsuo Danggui Wan（NDW） and Danggui Pian（DP）,as well as the quality correlation with radix Angelica sinensis raw materials（Danggui）.As Chinese patent drugs containing single ingredient of Danggui,the remarkable differences between NDW and DP in the content and distribution of components in fingerprint chromatograms were observed,mainly due to different processing methods and techniques.However,the chromatographic profiles of the same type of samples were generally consistent though the absorption intensities of some common peaks were different,and the similarity values of the NDW samples to Danggui herb were slightly higher than that of the DP samples.The quality consistency and stability of DP samples from different manufacturers and different batches were better than that of NDW.The quality differences of the different batches of NDW or DP samples from the same manufacturer were small.A few marker peaks among the 24 common peaks in chromatographic fingerprints of Danggui were pinpointed by comparing with the fingerprint chromatograms of Chinese patent drug NDW and DP,which were likely to contribute significantly to the pharmacodynamic activities of Danggui. |
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