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| Simultaneous Determination of Total Specific Migration Limit of 9 Types of Ultraviolet Absorbers in Food Simulants by High Performance Liquid Chromatography-Tandem Mass Spectrometry |
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| DOI： |
| KeyWord:high performance liquid chromatography-tandem mass spectrometry（HPLC-MS/MS） ultraviolet absorbents total specific migration limit food simulants |
| Author | Institution |
| XIAO Xiao-feng，WANG Jian-ling*，CHEN Tong，LIU Ting-fei，HE Jun，DENG Hong-yi，YANG Juan-juan |
台州出入境检验检疫局 |
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| Abstract: |
| A novel method for the simultaneous determination of total specific migration limit of UV-24，UV-0，UV-9，DHBP，UV-531，HHBP，UV-P，UV-327 and UV-326 in food simulants（10% ethanol，20% ethanol，50% ethanol，3% acetic acid and olive oil） was developed using high performance liquid chromatography-tandem mass spectrometry（HPLC-MS/MS）.After the migration test，the soaking solution was cooled down，and homogenized.Olive oil food simulant was extracted with acetonitrile and n heptane，the clear acetonitrile solution and other aqueous food stimulant diluted with ethanol（1∶10） were filtered through a hydrophilic polytetrafluoroethylene filter with a disposable syringe before injection.The SunFireTM C8 column and gradient elution were selected to separate.The AB Qtrap 4500 tandem quadrupole mass spectrometer was operated under multiple reaction monitoring（MRM） and ESI-mode.The limits of quantitation were between 0.01 mg/kg and 0.30 mg/kg.The linearity of the method was good with correlation coefficients（r） not less than 0.995 4 over the certain concentration range .The recoveries at spiked concentration levels of 1-35 mg/kg were between 80.0% and 127% with relative standard deviations of 0.8%-8.0%.With the high sensitivities，good recoveries and accuracies，the method could be applied for the analysis of food contact material samples. |
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