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| Study on Interaction between Loureirin and Human Serum Albumin by Pressure mediated Affinity Capillary Electrophoresis Method |
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| DOI： |
| KeyWord:affinity capillary electrophoresis loureirin A loureirin B cochinchinenin C human serum albumin(HSA) binding constant |
| Author | Institution |
| QIAN Kai，CHEN Xu，CHEN Qin* |
上海大学生命科学学院 |
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| Abstract: |
| The interactions of loureirin A(LA)，loureirin B(LB) and cochinchinenin C(CC) with human serum albumin(HSA) under simulated physiological conditions(pH 74) were studied by pressure-mediated affinity capillary electrophoresis method(P-ACE).The binding constants were 0414×105，0252×105 ，1816×105 L/mol for LA，LB and CC，respectively.The results showed that P-ACE was a useful method to study the interaction between drug and protein. |
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