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| Simultaneous Determination of Furfural,5-Hydroxymethylfurfural and 5-Methylfurfural in Cigarette Fragrances by Ultra-high Performance Liquid Chromatography |
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| DOI： |
| KeyWord:ultra-high performance liquid chromatography（UPLC） cigarette fragrances furfural 5-hydroxymethylfurfural 5-methylfurfural |
| Author | Institution |
| REN Hu-bo,BIE Zhen-ying,ZHU You,WEI Yi-pei,CHEN Yu-song,LUO Xu,ZHANG Fu-min,JI Li-shun* |
山东省烟草专卖局（公司）质量监督检测站 |
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| Abstract: |
| An ultra-high performance liquid chromatographic（UPLC）method for the simultaneous determination of furfural,5-hydroxymethylfurfural and 5-methylfurfural in cigarette fragrances was established.After dilution,vibration and filtration,the cigarette additives were separated on a C18（2.1 mm i.d.× 100 mm,1.7 μm） column under isocratic elution mode using acetonitrile-water（10∶90） as mobile phase at a flow rate of 0.3 mL/min.The quantification of these analytes was achieved by the external standard method with a diode-array detector at 280 nm.Baseline separation of these analytes was achieved within 5.0 min.The linear ranges for 5-hydroxymethylfurfural,furfural and 5-methylfurfural were in the ranges of 0.004 2-40.00 mg/kg,0.004 6-30.00 mg/kg,0.006 9-30.00 mg/kg,with correlation coefficients（r2） of 0.999 2,0.999 9 and 0.999 8,respectively.The detection limits（S/N=3） for three analytes were 1.24,1.37,2.06 μg/kg,respectively.Relative standard deviations（RSD,n=11） were in the range of 0.1%-0.4%.The recoveries at spiked concentration of 0.005 0-10.18 mg/kg were 91.7%-106.0%.The proposed method has the merits of easy operation,fast analysis and accurate results,and is suitable for the simultaneous determination of 5-hydroxymethylfurfural,furfural and 5-methylfurfural in cigarette fragrances. |
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