|
| Metabolomic Comparison of Serum Samples in Different Groups of SD Rats |
| |
| View Full Text Download reader |
| DOI： |
| KeyWord:metabolomics serum rats biological samples 1H NMR |
| Author | Institution |
| ZHANG Song，LI Zhen-yu*，QIN Xue-mei* |
1.山西省分析科学研究院核磁共振检测研究室;2.山西大学中医药现代研究中心 |
|
| Hits: 2325 |
| Download times: 1751 |
| Abstract: |
| To explore the differences in body metabolism of experimental animals，the serum samples of four batches of healthy SD rats raised in different periods were compared using proton nuclear magnetic resonance(1H NMR) based metabolomic approach combined with multivariate statistical analysis.The results showed that the contents of several serum metabolites in different groups，including citric acid，pyruvic acid，succinic acid，glutamine，dimethylglycine，changed slightly，while the amounts of alanine，arginine，isoleucine，lactic acid，3-hydroxybutyric acid and choline were fluctuant.Further metabolic pathways analysis showed that amino acid metabolism，ketone body metabolism and choline metabolism were fluctuant in different groups of SD rats.This study provided a new method for the evaluation on the consistency among the different groups of healthy SD rats，and laid a basis for further determination on the biomarkers in serum samples. |
| Close |