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| Determination of Three Restricted Flavor Additives in Cigarettes by Solid phase Extraction with Gas Chromatography-Tandem Mass Spectrometry |
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| DOI： |
| KeyWord:solid phase extraction(SPE) gas chromatography-tandem mass spectrometry(GC-MS/MS) restricted flavor additives cigarettes |
| Author | Institution |
| ZHENG Yang,XU Xiu-li,JI Shun-li,YUAN Fei,HUANG Zhi-qiang,YANG Bing-cheng*,ZHANG Feng* |
1.华东理工大学药学院;2.中国检验检疫科学研究院烟草安全与控烟技术中心/食品安全研究所;3.湖南检验检疫科学技术研究院 |
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| Abstract: |
| An analytical method for the simultaneous determination of three restricted flavor additives(3-thujanone,camphor and safrole) in tobacco products by solid-phase extraction with gas chromatography-tandem mass spectrometry(GC-MS/MS)was developed and evaluated.The extraction conditions and MS conditions were optimized.Under the optimal conditions,three flavor additives had good linearities in the range of 10.0-500.0 μg/L,with correlation coefficients(r2) not less than 0.998 6.The limits of detection(LODs) and limits of quantitation(LOQs) for these additives were in the ranges of 2.3-5.8 μg/kg and 7.7-19.3 μg/kg,respectively.The average recoveries of three analysts were in the range of 74.9%-90.9% at three spiked levels of LOQ,1.5 LOQ and 2 LOQ,with relative standard deviations(RSDs) not more than 2.6%.The method is accurate,reliable and sensitive,and could satisfy the requirements for detection of three restricted flavor additives in domestic. |
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