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| Rapid Determination of Diclazuril,Toltrazuril and Their Metabolite Residues in Foods of Animal Origin by On line Cleanup Liquid Chromatography-High Resolution Mass Spectrometry |
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| DOI： |
| KeyWord:on-line cleanup obitrap high resolution mass spectrometry diclazuril toltrazuril toltrazurilsulfone toltrazuril sulfoxide foods of animal origin |
| Author | Institution |
| ZHANG Hai-chao，MA Yu-song,LI Ying，AI Lian-feng，XU Niu-sheng，CHEN Rui-chun，GUO Chun-hai |
1.河北出入境检验检疫局;2.赛默飞世尔科技（中国）有限公司 |
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| Abstract: |
| A new method was developed for the rapid determination of diclazuril，toltrazuril，toltrazurilsulfone and toltrazurilsulfoxide residues in foods of animal origin by on line cleanup liquid chromatography-high resolution benchtop quadropole/obitrap mass spectrometry（HRMS） .The samples were extracted with acetonitrile，and purified on a Cyclone column.The analytes were eluted from the exaction column and put into a C18 analytical column prior to chromatographic separation and detection in full scan/ddMS2 mode.The calibration curves were linear in the range of 0.5-50 ng/mL with correlation coefficients more than 0.999 4.The limits of quantitation（LOQ） were 2 μg/kg.Average recoveries of the analytes in four matrices ranged from 80.2% to 110.5%，with relative standard deviations of 2.8%-9.7%.With simple pretreatment，low matrix effects,this method could be used for the rapid confirmation with accurate mass of quasi molecular ion，retention time，isotope ratio and qualitative fragments. |
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