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| Specific Recognition of Pathogenic Bacterium towards Glycan and Its Applications in Analytical Chemistry |
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| DOI： |
| KeyWord:carbohydrate-lectin interactions multivalent interactions bacterial adhesion bacterial detection review |
| Author | Institution |
| CUI Fei-yun,XU Yi,ZHAO Bin,CHE Yu-lan,LIU Lu-lu |
1.重庆大学化学化工学院;2.重庆大学光电工程学院微系统研究中心;3.重庆大学新型微纳器件与系统技术国防重点学科实验室;4.重庆大学微纳系统及新材料技术国际研发中心 |
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| Abstract: |
| Pathogen adhesion to host tissue is a prerequisite for a majority of infectious diseases.A common way for accomplishing adhesion is specific recognition of bacterium cellular lectins towards glycan on the surface of the host cells.Therefore,research on pathogenic bacteria-glycan interactions is beneficial to further understand the pathogenic mechanism of infectious diseases.Meanwhile,it could provide new strategies for specific detection on pathogenic bacteria and treatment of infectious diseases,and the mechanisms related with adhesion of pathogenic bacteria,carbohydrate-lectin interactions and multivalent interactions were summed up.The analysis technologies of pathogenic bacteria-glycan interactions were introduced,especially,the latest development and research of surface plasmon resonance,quartz crystal microbalances,fluorescence spectrum and electrochemical impedance spectroscopy were summarized.Special attention was paid to the combination of those detecting technologies and microfluidic chip platforms.In view of the serious problems of antibiotics resistance and poor specificity of pathogenic bacteria detection,the applications of bacterial isolation,enrichment,detection,identification,biofilm inhibition and the screening of antimicrobial agents were reviewed.Finally,the future development for basic research and application of pathogenic bacteria-glycan interactions were prospected. |
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