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| Determination of 2-Bromo-2-nitro-1，3-propanediol in Cosmetics by High Performance Liquid Chromatography-Inductively Coupled Plasma Mass Spectrometry |
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| DOI： |
| KeyWord:high performance liquid chromatography(HPLC) inductively coupled plasma mass spectrometry(ICP-MS) 2-bromo-2-nitro-1,3-propanediol cosmetics |
| Author | Institution |
| WANG Mei-bo，ZHONG Ji-qiang，CHEN Dan-dan，MAO Bei-ping，WANG Xin-mei，ZHENG Rong，LIU Chang，WANG Ke |
上海市食品药品检验所 |
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| Abstract: |
| A new method was established to determine 2-bromo-2-nitro-1，3-propanediol in cosmetics by high performance liquid chromatography-inductively coupled plasma mass spectrometry(HPLC-ICP-MS). The analyte was separated on a ZORBAX-C8 column (150×2.1 mm， 5 μm) using methanol-water-5% phosphoric acid (10 ∶ 985 ∶ 5， pH value was adjusted to 3.0 with 2 mol/L NaOH) as mobile phase. The flow rate was set at 0.7 mL/min. The column temperature was room temperature. The results indicated that the calibration curve of 2-bromo-2-nitro-1，3-propanediol was linear in the range of 0.01-1.0 mg/L，with a correlation coefficient(r) of 0.999 9. The detection limits of different matrix samples were all 1.0 μg/g. The spiked recoveries of 2-bromo-2-nitro-1，3-propanediol ranged from 94.6% to 101.3%， with RSDs(n=6) of 1.5%- 4.5%. The method showed the advantages of rapidness，sensitivity，accuracy and little interference，and it could be used for the qualitative and quantitative determination of 2-bromo-2-nitro-1，3-propanediol in cosmetics. |
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