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| Synthesis and Properties of Al3+ Fluorescence Probe Based on β-Carboline and Schiff Base |
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| DOI： |
| KeyWord:β-carboline quinolone schiff base Al3+fluorescent probe |
| Author | Institution |
| HAN Ya-lian,DAN Fei-jun,LIU Lu-lu,ZENG Min,CHEN Ling,LAN Hai-chuang |
三峡大学生物与制药学院 |
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| Abstract: |
| (2-Hydroxybenzylidene)-1-(quinolin-2-yl)-9H-pyrido-［3,4-b］ indole-3-carbohydrazide(QCS) was synthesized by a series of reactions with L-tryptophan methyl ester hydrochloride and 2-quinolinecarboxaldehyde as raw material. The structure of QCS was characterized by 1H NMR,13C NMR and ESI-MS. The probe QCS has a specific response to Al3+,and the limit of detection was 4.40×10-9 mol/L. QCS showed a good linearity in the concentration range of 9-100 μmol/L with a correlation coefficient(r2) of 0.999 1. In a mixed system of ethanol-water(9∶1,by volume),the binding ratio of QCS and Al3+ was 1∶1,and the complexing constant was proved to be(2.91±0.22)×103(mol/L)-1 in the fluorescence titration spectra. Furthermore,the fluorescent intensity of QCS-Al3+ maintained stable in the pH 5.0-8.0,which satisfied the requirements for detection on environmental water samples and living cells. |
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