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| Determination on Migration of Bisphenol A,Bisphenol F and Bisphenol S in Food Contact Materials by Liquid Chromatography-Tandem Mass Spectrometry |
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| DOI： |
| KeyWord:food contact materials bisphenol A bisphenol F bisphenol S liquid chromatography tandem mass spectrometry |
| Author | Institution |
| LIANG Xi-zhen,SUI Hai-xia,LI Dan,ZHONG Huai-ning |
1.广东出入境检验检疫局检验检疫技术中心;2.国家食品安全风险评估中心 |
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| Abstract: |
| A high performance liquid chromatography-tandem mass spectarometry was established for the determination on migration amounts of bisphenol A,bisphenol F and bisphenol S in food contact materials.Bisphenol A,bisphenol F and bisphenol S were transfered into the food simulants in the sample contacted at a certain temperature and time.The separation was performed using a C18 chromatographic column with methanol-ammonia as mobile phase.Under the electrospray ionization(ESI)mode,bisphenol A,bisphenol F and bisphenol S were detected in a multiple-reaction monitoring mode(MRM),and quantified by the external standard method.The method indicated a perfect performance in chromatographic separation.The calibration curves of bisphenol A and bisphenol F were linear in the range of 1-50 μg/L,while the calibration curve of bisphenol S was linear in the range of 0.1-50 μg/L.The limits of detection were 0.3 μg/L for bisphenol A and bisphenol F,and 0.05 μg/L for bisphenol S.The recoveries ranged from 83.6%to 102.6%,with relative standard deviations(RSDs) of 3.5%-8.9%.This method was rapid,accurate,precise and convenient,and was appropriate for the determination of bisphenol A,bisphenol F and bisphenol S in food contact materials. |
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