| A gas chromatography-triple quadrupole mass spectrometric（GC-MS/MS） method for the determination of 48 pesticide residues in high-acidity fruits was developed using solid-phase extraction as sample preparation method.The samples were extracted with acetonitrile containing 1% acetic acid，purified with a CarbonNH2 and ProElutNH2 solid phase extraction column,and analyzed by GC-MS/MS.Effects of different kinds of extractants，extraction times and types of SPE column on the extraction efficiency were investigated by using pomelo,orange,pineapple and hawthorn matrixes.The results showed that the calibration curves of 48 pesticides were linear in the range of 1.0-100.0 μg/kg with limits of quantitation of 1.0-10.0 μg/kg.The average recoveries for 48 pesticides in four kinds of fruits（pomelo,orange,pineapple and hawthorn） ranged from 70.7% to 118.0% with relative standard deviations（RSD,n=5） not more than 9.7%.With wide detection range,high precision and low detection limit,the method was successfully applied in the detection of commercially available fruit samples. |