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| Determination of Minocycline Hydrochloride Using a Novel Fluorescence Turn-on Method Based on Rapeseed Carbon Quantum Dots |
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| DOI： |
| KeyWord:carbon quantum dots rapeseed minocycline hydrochloride “off-on”fluorescent probe potassium permanganate |
| Author | Institution |
| WU Wen-bo,ZHANG Yue-cheng,MA Hong-yan,TIAN Rui,LIU Xiao-li |
College of Chemistry and Chemical Engineering,Yanan Key Laboratory of Analytical Technology and Detection,Yanan University |
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| Hits: 2015 |
| Download times: 1126 |
| Abstract: |
| In this paper,a new fluorescent carbon quantum dots（CQDs）were synthesized by one-step method using rapeseed and water as raw material.The experiments showed that potassium permanganate（KMnO4）could effectively quench the fluorescence of the CQDs.However,the fluorescence of CQDs-KMnO4 system restored reversibly in the presence of minocycline hydrochloride.Based on this principle,a new method was proposed for the determination of minocycline hydrochloride with the“off-on”fluorescence signal of rapeseed CQDs as a fluorescent probe.Under the optimum conditions,the linear range of the method was 5.0×10-7 mol/L to 1.0×10-5 mol/L with a correlation coefficient of 0.999 5 and a detection limit of 4.9×10-7 mol/L.The method was used in the determination of minocycline hydrochloride in samples with a recovery of 99.6%-100%.The mechanisms for CQDs fluorescence quenched by KMnO4 and recovered by minocycline hydrochloride were studied. |
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