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| Recent Advances in Applications of Mass Spectrometry in Discovering Biomarkers for Ischemic Stroke |
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| DOI： |
| KeyWord:mass spectrometry ischemic stroke biomarkers proteins metabolites |
| Author | Institution |
| WANG Jian-ying，WU Qian，YAO Zhong-ping |
1.State Key Laboratory of Chemical Biology and Drug Discovery,Food Safety and Technology Research Centre,Department of Applied Biology and Chemical Technology,The Hong Kong Polytechnic University,Hung Hom,Kowloon,Hong Kong,China;2.State Key Laboratory of Chinese Medicine and Molecular PharmacologyIncubation,Shenzhen Key Laboratory of Food Biological Safety Control,Shenzhen Research Institute of The Hong Kong Polytechnic University,Shenzhen,China |
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| Abstract: |
| Stroke is one of the leading causes for death and disability in the world,while ischemic stroke(IS) constitutes around 87 percent of stroke cases.Medical treatment should typically be made within 3 or 45 hours of stroke onset.Rapid diagnosis and early screening on IS are thus of great significance,and molecular biomarker is an effective strategy for this.Mass spectrometry is a choice of technique for detection of various compounds in biomedical samples,and has played important roles in discovery of biomarkers for IS.In this review,the recent advances in discovering biomarkers of IS,particularly those of the protein and metabolite biomarkers,are summarized and commented. |
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