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| Preparation of N-doped Ordered Mesoporous Carbon Modified Electrode by Hard Template Method for Detection of Nefopam Hydrochloride |
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| DOI： |
| KeyWord:N-doped mesoporous carbon modified electrode cyclic voltammetry nefopam hydrochloride |
| Author | Institution |
| CHENG Hao，FAN Jing-jing，LIU Yong-yi |
1. Guangxi Liuzhou Luosifen Research Center of Engineering Technology， Guangxi Key Laboratory of Green Processing of Sugar Resources， College of Biological and Chemical Engineering， Guangxi University of Science and Technology， Liuzhou ， China; 2. Liuzhou Institutes for Food and Drug Control， Liuzhou ， China; 3. Province and Ministry Co-sponsored Collaborative Innovation Center of Sugarcane and Sugar Industry， Nanning ， China |
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| Abstract: |
| Different N-doped mesoporous carbons（N－CMK－3） were prepared by hard template method， using melamine， urea and ethylenediamine as nitrogen source， arabinose as carbon source and mesoporous silicon （SBA－15） as template agent. The samples were characterized by scanning electron microscopy（SEM）， transmission electron microscopy（TEM）， brunner emmet teller（BET）， X-ray diffraction（XRD） and X-ray photoelectron spectroscopy（XPS）. The N－CMK－3 were coated onto glassy carbon electrodes to construct electrochemical sensors. The electrochemical characteristics of N－CMK－3 modified electrodes were investigated by cyclic voltammetry. Effects of amount of modifier and pH value on the electrochemical behavior of nefopam hydrochloride were investigated. The results showed that， under the optimal experimental conditions of 6 μL modified dose and pH 4.5， nefopam hydrochloride had a good linear relationship（r2 = 0.992） between peak current and its concentration within 1.0 × 10－8－5.0 × 10－6 mol/L. The limit of detection（LOD， S/N = 3） was 5.3 × 10－9 mol/L．This method was applied to the detection of nafopam hydrochloride in human nafopam hydrochloride tablets， with recoveries of 95.9%－100%. |
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