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| Progress on Application of Covalent－Organic Frameworks-based Stationary Phases in Chromatography |
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| DOI： |
| KeyWord:covalent－organic framework stationary phase high performance liquid chromatography（HPLC） gas chromatography（GC） capillary electrochromatography（CEC） |
| Author | Institution |
| LI Xue，YANG Cheng-xiong |
1. State Key Laboratory of Component-based Chinese Medicine， Tianjin University of Traditional Chinese Medicine， Tianjin ， China; 2. College of Chemistry， Research Center for Analytical Science， Nankai University， Tianjin ， China |
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| Abstract: |
| Covalent organic frameworks （COFs）are a recent class of porous functional materials composed of diverse light elements （C， H， O， N and B）through various robust covalent bonds. Their unique properties such as large surface areas， excellent stabilities， tunable pores， diverse functions and designable structures make COFs quite promising in analytical chemistry such as sample pretreatment and chromatographic separation. COFs used as novel stationary phases in high performance liquid chromatography （HPLC）， gas chromatography （GC）and capillary electrochromatography （CEC）have attracted great concerns recently. COFs with large surface area， good thermal and chemical stability are ideal candidates in GC. The good solvent stability and large surface area also make COFs potentially useful in HPLC and CEC. COFs used in chromatographic separation all possess good chemical stability， but have different specific surface area， topological structures， pore sizes， properties and selectivities， and are suitable for the resolution of different types of targets such as small organic molecules， position isomers and even chiral compounds. This review presents the recent progress on applications of COFs-based stationary phases and columns in chromatography. The preparation and applicability of these COFs-based stationary phases and columns in chromatographic separation are discussed. The application prospect of COFs in chromatographic separation is also presented. |
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