|
| Detection of Oxcarbazepine Using an Electrochemical Sensor Based on Magnetic Molecularly Imprinted Membrane |
| |
| View Full Text Download reader |
| DOI： |
| KeyWord:molecularly imprinted membrane ?electrochemical sensor ?magnetic carbon paste electrode ?detection ?oxcarbazepine |
| Author | Institution |
| ZHANG Di， LI Qiang-xiang， WANG Zhi-mei， LIAO Li-fu，XIAO Xi-lin |
1. School of Chemistry and Chemical Engineering，Hunan Province Key Laboratory for the Design and Application of Actinide Complexes，University of South China，Hengyang ，China;2. Ningxia Medical University Affiliated People's Hospital of Autonomous Region，Yinchuan ，China;3. State Key Laboratory of Chemo/Biosensing and Chemometrics，Hunan University，Changsha ，China |
|
| Hits: 1397 |
| Download times: 1118 |
| Abstract: |
| In this paper，a magnetic molecularly imprinted electrochemical sensor（MNPs－MIP/ MCPE）for the detection of oxcarbazepine（OXC）was prepared，using 4-vinylpyridine and methacry? late as raw materials. Firstly，according to the calculation of the density functional theory（DFT/ B3LYP/6－31 + G），the best combination and the best combination ratio of the OXC with functional monomers were successfully screened and constructed. Subsequently，a magnetic molecularly im? printed membrane（MNPs－MIP）capable of recognizing OXC was synthesized based on the precipita? tion polymerization method，which was coated on the surface of a carbon paste electrode（MCPE）to make a magnetic molecularly imprinted sensor of MNPs－MIP/MCPE. The sensor was used for the de? termination of different concentrations of OXC solutions with differential pulse voltammetry（DPV）. Results showed that，the current signals of the system had good linear relationship（r > 0. 999）with OXC concentrations in the ranges of 5 × 10－8 －3 × 10－6 mol/L and 3 × 10－6 －1. 5 × 10－4 mol/L，and their linear equations were Ip （μA）= 1. 755 + 1. 097c（μmol/L）and Ip （μA）= 0. 131 + 5. 177c （μmol/L），respectively. The detection limit for OXC（LOD = 3S/m）was 2. 06 × 10－8 mol/L. The sen? sor was used for the detection of OXC concentration in the actual samples，with recoveries of 99. 4%－ 101% and relative standard deviations（RSD）of 1. 5%－2. 5%. |
| Close |