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| Determination of Neopentyl Glycol Migra? tion in Food Contact Materials and Prod? ucts by Liquid Chromatography－Tandem Mass Spectrometry |
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| DOI： |
| KeyWord:liquid chromatography-tandem mass spectrometry ?food contact material ?neopentyl glycol ?migration |
| Author | Institution |
| LI Ze-rong， GUO Xu-dong， LING Guang-yao， CHEN Yi-guang， XIONG Xiao-ting， LI Lu， GUO Pei-chun，LIU De-yun，WU Xiao-chun，XIE Wenjian，HUANG Xiao-gang |
National Packaging Product Quality Supervision and Inspection Center（Guangzhou），Guangzhou Quality Supervision and Testing Institute，Guangzhou ，China |
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| Abstract: |
| A liquid chromatography－tandem mass spectrometry（LC－MS/MS） was established for the determination of neopentyl glycol in food contact materials and products in this paper. Water， 4% acetic acid（volume fraction）， 10% ethanol， 20% ethanol， 50% ethanol， 95% ethanol and olive oil were used as the food simulants. After soaking in food simulants， different types of soaking solutions were pretreated with appropriate manners. Water， 4% acetic acid and 10% ethanol soaking solutions were directly filtered and injected. For soaking solutions of other ethanol simulants， most of the ethanol was removed by nitrogen blowing in a certain volume， and water was used to replenish to the original volume. For olive oil soaking solution， 10% ethanol was used for extraction. The separation was performed on an ACQUITY UPLC? BEH C18（50 mm × 2.1 mm， 1.7 μm） chromatographic column by gradient elution， with 0.01% formic acid solution and acetonitrile as mobile phases. The detection was performed with electrospray ion source in positive ion（ESI+） multi reaction monitoring（MRM） mode. External standard method was used for quantitative determination. Under the optimized conditions， there was a good linear relationship for neopentyl glycol in the range of 10－100 μg/L（μg/kg）， with its correlation coefficient larger than 0.999. The spiked recoveries for neopentyl glycol at three spiked levels of 10， 20 and 100 μg/L（or μg/kg） ranged from 92.8% to 117%， with relative standard deviations（RSD） of 0.90%－8.6%. The limit of detection（LOD，?S/N ≥ 3） was 5 μg/L（or μg/kg）， while the limit of quantitation（LOQ， S/N ≥ 10） was 10 μg/L（or μg/kg）. The method was simple， stable， reliable and sensitive. The food simulants included in the method basically covered the types specified in the regulations and standards. The LOD and LOQ of the method were lower than the specific migration limit（SML） specified in the regulations and standards. The method could not only meet the needs for determination of neopentyl glycol migration in food contact materials and products， but also provide a reliable technical means for related product supervision and quality control. |
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