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| Determination of α-Chlorotoluene in Cos? metics by Headspace Gas Chromatogra? phy－Mass Spectrometry |
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| DOI： |
| KeyWord:α-chlorotoluene ?cosmetics ?benzalkonium chloride ?thermal degradation ?headspace gas chromatography－mass spectrometry （HS－GC－MS） |
| Author | Institution |
| LIU Hua-chun， LIANG Wen-yao， WANG Ji-cai， XIA Ze-min， XIONG Xiao-ting， PENG Rong-fei， TAN Jian-hua |
1. Guangzhou Center for Disease Control and Prevention，Guangzhou ，China;2. Guangzhou Quality Supervision and Testing Institute，National Quality Supervision and Testing Center for Cosmetics（Guangzhou）， Guangzhou ，China |
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| Abstract: |
| A method was developed for the determination of α-chlorotoluene in cosmetics containing benzalkonium chloride. Firstly， the thermal decomposition products of benzalkonium chloride was analyzed by gas chromatography－mass spectrometry（GC－MS）. A phenomenon was confirmed that benzalkonium chloride and similar compounds will decompose into α-chlorotoluene at the inlet of GC－MS. Then， a new analytical method for α-chlorotoluene in cosmetics was developed by a headspace injection mode of gas－liquid equilibrium. The headspace sampling parameters， chromatographic separation and mass spectrometry conditions were optimized. The equilibrium temperature and time for headspace sampler were set at 80 ℃ and 30 min， respectively. The sample was dissolved with 8 mL water and 1.0 g sodium chloride in headspace bottle. The analytes were separated on an HP－INNOWax column（60 m × 0.25 mm × 0.25 μm）， then detected in selectedion monitoring mode and quantified by external standard method. Results showed that the standard curves for α-chlorotoluene were linear over the concentration range of 0.01－5.00 μg/mL with linear correlation coefficients（r） of 0.999. The detection limits and quantification limits of the method were 0.02 μg/g and 0.05 μg/g， respectively. The spiked recoveries ranged from 91.3% to 98.8% with relative standard deviations（RSDs） of 1.5%－4.9%. The method is simple， rapid， high sensitive and specific， and it is suitable for the determination of α-chlorotoluene in cosmetics. |
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