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| Rapid Analysis of Additives in Cosmetics Using Antireflection Surfaces Laser Desorption Ionization Mass Spectrometry |
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| DOI： |
| KeyWord:antireflection surface laser desorption ionization mass spectrometry（AR－LDI MS） additives cosmetics rapid analysis |
| Author | Institution |
| TAN Ao-lei，MA Xiao-xiao |
State Key Laboratory of Precision Measurement Technology and Instruments，Department of Precision Instrument，Tsinghua University，Beijing ，China |
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| Abstract: |
| There are many kinds of additives in cosmetics．Addition of these substances could improve the use effect and shelf life of cosmetics，but excessive use may result adverse effects on human health．In this study，a rapid method for analysis of additives in cosmetics was established by antireflection surfaces laser desorption ionization mass spectrometry（AR－LDI MS）．The detection limits for 3-benzylidene camphor，4-methylbenzylidene camphor，p-hydroxyacetophenone and cyclopyridone in cosmetics were 4， 6， 40 and 10 mg/kg，respectively．The quantitative analysis of camphor derivatives including 3-benzylidene camphor and 4-methylbenzylidene camphor in cosmetics could also be realized by adding the internal standard，within linear range of 60－140 mg/kg．With simple pretreatment process，short analysis time（not more than 5 min），good sensitivity and accuracy，the method has a broad application prospect in the in-situ rapid detection of cosmetics． |
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